Now that a number of people have it, the general consensus seems to be that it's too big to comfortably use with one hand.  Also handwriting isn't terribly good because you can't rest your hand on the screen, so writing is a little awkward.

Otherwise, the screen is the obvious plus (PenTile not an issue), and the device is light.
I'll probably go for the Galaxy Nexus as the screen is big enough and for smaller size.