madVR has rather slow initialisation, and flickers with certain events.  For example, pausing will cause a flicker (and a bit of some noticeable acceleration of playback for about half a second), going into full screen will flicker and lag for a second.  Alt-tabbing back to the player's window (paused video) gives me a black screen (need to hit play to see anything).
Could be I'm using an old version, but I find it rather annoying.

EVR Sync on main PC, Overlay on netbook.
IDK if best, meh, I can't really tell the difference anyway, especially since I fiddle with brightness/contrast settings of screens.