I have a feeling it'll move towards drama, as the whole situation seems to be designed for it, but they may keep it in a somewhat positive tone.
Despite this, I don't think this show will try to make much of comment on the idea of a future filled with androids (unlike Chobits, for example) - at least not in a negative sense.

Isla's enthusiastic/clumsy girl personality, who's gonna die is indeed an interesting mix.  How she degrades throughout the show (and changes) is likely going to be a central topic.

I think the sensation of unease may be the goal here.